Localization: Plasma
Plasma concentration: 40 µg/ml (3)
Mode of action: Zymogen; precursor to the serine protease factor XIIa;
activated by kallikrein/HMWK/anionic surface complex to
intitiate the intrinsic pathway
Molecular weight: 80,000 (2)
Extinction coefficient: E1 cm, 280 nm = 14.0
Isoelectric point: 6.8
Structure: single chain (Mr = 80,000), organized into 6 domains based
on sequence homology (5)
Percent carbohydrate: 17%
艾美捷人因子Ⅻ HCXII-0155相关参数：
Localization: 等离子
血浆浓度：40µg/ml（3）
作用方式：Zymogen；丝氨酸蛋白酶因子XIIa的前体；
激肽释放酶/HMWK/阴离子表面复合物激活
阐明内在途径
分子量：80000（2）
消光系数：E1 cm，280 nm=14.0
等电点：6.8
结构：单链（Mr=80000），基于6个域组织
关于序列同源性（5）
碳水化合物百分比：17%
人因子Ⅻ HCXII-0155文献参考：
1. Schmaier, A.H., et al., in Hemostasis and Thrombosis, ed. R.W. Colman, J. Hirsh, V.J. Marder and
E.W. Salzman, pp 18-38, J.B. Lippincott Company, Philadelphia, 1987.
2. Griffin, J.H. and Cochrane, C.G., Methods Enzymol., 45, 56-65 (1976).
3. Saito, H., et al., J Lab Clin., 88, 506 (1976).
4. McMullen, B.A. and Fujikawa, N., J. Biol. Chem., 260, 5328 (1985).
5. Davie, E.W., in Hemostasis and Thrombosis, ed. R.W. Colman, J. Hirsh, V.J. Marder and E.W.
Salzman, pp 242-267, J.B. Lippincott Company, Philadelphia, 1987.
6. Griffin, J.H., Proc. Natl. Acad. Sci. USA, 75, 1998 (1978).
7. McMillin, L.R., et al., J. Clin. Invest., 54, 1312 (1974).
8. Revak, S.D., et al., J. Clin. Invest., 59, 1167 (1977).
9. Fujikawa, K., et al., Biochemistry, 16, 4182 (1977).
10. Bonno, N., et al., in New Comprehensive Biochemistry, ed. R.F.A. Zwaal and H.C.Hemker,
pp. 103-128, Elsevier, Amsterdam, 1986.
11. Claeys, H. and Collen, D. (1978) Eur. J. Biochem., 87, 69 (1978).
12. Revak, S.D. and Cochrane, C.G., J. Clin. Invest., 57, 852 (1976).
13. Cochrane, C.G., et al., J. Exp. Med., 138, 1564 (1973).
14. Revak, S.D., et al., J. Exp. Med., 147, 719 (1978).
15. Ghebrehiwet, B., et al., J. Clin. Invest., 71, 1458 (1983).
16. DeAgostini, A., et al., J. Clin. Invest., 73, 1542 (1984).
17. Rathoff, O.D., et al., J. Exp. Med., 129, 315 (1969).
18. Stead, N., et al., J. Biol Chem., 251, 6481 (1976).
19. Pixley, R.A., et al., J. Biol Chem., 260, 1723 (1985).
20. Gjonnass, H., Thromb. Diath. Haemorrh., 28, 182 (1972).
21. Radcliffe, R., et al., Blood, 59, 611 (1977).
