SCREEN-WELL生物活性脂质库包含 190 种 96 孔格式的生物活性脂质。非常适合筛选或鉴定重组孤儿 G 蛋白偶联受体、靶标验证、二次筛选、验证新测定和常规药理学应用。
The SCREEN-WELL® Bioactive Lipid Library contains 190 bioactive lipids in a 96 well format. Ideal for screening or identifiying recombinant orphan G protein-coupled receptors, target validation, secondary screening, validating new assays and for routine pharmacological applications.
Applications: HTS
Contents: 190 compounds including: Agonists & Antagonists, Endocannabinoids, Farnesyl/geranylgeranyl derivates, HETEs deHETEs, hepoxilins, Polyunsaturated fatty acids, Leukotrienes, lipoxins, LPA & phosphatidic acids, Octadecanoids, PAFs, Prostaglandins & thromboxanes, Retinoids, vitamin D metabolites, Sphingolipids.
Quantity: 100 or 500µl per well.
Concentration: DMSO solutions (1.0 or 0.1mM, depending on compound).
Use/Stability: Stable for at least one year from the date of receipt when stored at -80°C.
Long Term Storage: -80°C
艾美捷SCREEN-WELL生物活性脂质库#BML-2800-0100相关参数说明：
内容： 190种化合物，包括：激动剂和拮抗剂，内源性大麻素，法呢基/香叶基香叶基衍生物，HETEs deHETEs，七氧西林，多不饱和脂肪酸，白三烯，脂氧素，LPA和磷脂酸，十八烷类，PAF，前列腺素和血栓素，类维生素A，维生素D代谢物，鞘脂。
数量： 每孔100或500μl。
浓度： DMSO溶液（1.0或0.1mM，取决于化合物）。
使用/稳定性：在-80°C下储存时，自收到之日起至少可稳定一年。
航运： 干冰
长期储存：-80°C
RUO - 仅供研究使用
SCREEN-WELL生物活性脂质库部分文献参考：
1.Molecular basis for the interaction of cellular retinol-binding protein 2 (CRBP2) with non-retinoid ligands: J. Silvaroli, et al.; J. Lipid Res. 62, 100054 (2021),
2.Mechanism of activation for the sirtuin 6 protein deacylase: M.A. Klein, et al.; J. Biol. Chem. 295, 1385 (2020),
3.Abnormal cannabidiol modulates vitamin A metabolism by acting as a competitive inhibitor of CRBP1: J.A. Silvaroli, et al.; ACS Chem. Biol. 14, 434 (2019),
4.Brown Adipogenic Reprogramming Induced by a Small Molecule: B. Nie, et al.; Cell Rep. 18, 624 (2017),
5.Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma: U.I. Scholl, et al.; J. Clin. Invest. 127, 2739 (2017),
6.AM251 Suppresses Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells: T. Yoshinaga, et al.; PLoS One 11, e0167848 (2016),
7.Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells: J.H. Rhim, et al.; Sci. Rep. 6, 26547 (2016),
8.Synthetic Ligands of Cannabinoid Receptors Affect Dauer Formation in the Nematode Caenorhabditis elegans: P.R. Rodrigues, et al.; G3 (Bethesda) 6, 1695 (2016),
