靶向抑制性协同受体PD-1和CTLA-4的检查点免疫疗法彻底改变了癌症治疗，而LAG-3作为新一代发现的抑制性检查点，有望成为肿瘤治疗中J具前景的靶点。
艾美捷ProSci LAG-3 重组蛋白的化学性质：
英文名称：LAG-3 Recombinant Protein
cat#：PSI-90-241
规格：50ug
来源宿主：CHO 细胞
溶解建议：开盖前，先离心。建议按说明书中要求的方式进行溶解和使用。
保存建议：Stable for at least 6 months after receipt when stored at -20˚C.
物种：人类
来源物种：人体细胞
重组蛋白序列：Leu23-Gly434
融合标签：C-6 his标签
艾美捷ProSci LAG-3 重组蛋白可以应用于已测试验证过的应用类型。
Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
Specications：
Species Human, Monkey, Mouse
Source Species CHO cells
Fusion Tag Fc Tag
Biological Activity
Inhibits binding of MAb to LAG-3 (human) to LAG-3. Induces maturation of human dendritic
cells.
Properties：
Purity
>99% (SDS-PAGE).<br><br> Endotoxin level is less than 0.1EU/ μg puried protein (LAL test;
Lonza).
Physical State Liquid
Buer In PBS.
Concentration 0.5 mg/ml
Storage Conditions Stable for at least 6 months after receipt when stored at -20°C.
